Lesha Ellison

South College PA Program
United States

Abstract Title: Evidence-Based Clinical Management of Polycystic Ovary Syndrome (PCOS)

Biography:

Lesha Ellison, MHS, PA-C, completed her master’s degree in physician assistant studies at South College Knoxville in 2016 and has been a principal faculty member and course director at South College Knoxville since 2021. She has integrated her clinical expertise in obstetrics and gynecology, gynecologic oncology, and women’s health into evidence-based PA education. She has presented at two conferences of the Tennessee Association of Physician Assistants and is dedicated to advancing clinical training, preceptor engagement, and student mentorship. With a strong background in high-risk populations and interdisciplinary care, she brings a patient-centered, academically rigorous approach to teaching and leadership within PA education.

Research Interest:

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects women in many ways, making personalized, evidence-based management essential. Lifestyle modification remains the foundation of care. Many women benefit from nutrition plans that focus on low glycemic index foods, Mediterranean patterns of eating, or anti-inflammatory strategies. When these are paired with regular aerobic and resistance exercise, improvements are often seen in insulin sensitivity, metabolic function, and reproductive health. Because PCOS can place a significant emotional burden on patients, especially when fertility is involved, supportive counseling may also enhance overall well-being. Metformin is recommended as the first-line medication for women with insulin resistance, particularly those with a body mass index of 25 or higher. It can improve glucose regulation, lower androgen levels, and support the return of regular menstrual cycles. GLP-1 receptor agonists, such as semaglutide, may be considered for women with obesity who need additional help with weight or metabolic control. When future fertility is desired, it is important to discuss reliable contraception while using these medications because pregnancy safety data are limited. Educating patients on how achieving a healthier weight can improve pregnancy outcomes may also improve the rate of compliance with the plan. For menstrual irregularity and signs of hyperandrogenism confirmed by elevated testosterone levels, combined oral contraceptive pills are first-line therapy. Spironolactone may be added when hirsutism persists. For women with morbid obesity, bariatric surgery may provide meaningful improvements in metabolic health, ovulation, and fertility. Clear patient education is essential to achieving the best outcomes.